Alzheimer's disease and related disorders annual, 2002 by Jeffrey L Cummings, Serge Gauthier

By Jeffrey L Cummings, Serge Gauthier

Given the improvement of latest healing concepts and items, Serge Gauthier and Jeffrey Cummings have compiled an inventory of up to date issues so as to be of curiosity essentially to neurologists concentrating on Alzheimer's ailment, and in addition to psychiatrists and geriatricians. The members, all revered of their subspecialties, have written up to date, comprehensively referenced chapters which should supply counsel in addition to stimulate dialogue on the place present remedy is heading.

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Extra resources for Alzheimer's disease and related disorders annual, 2002

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Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice. Proc Natl Acad Sci USA 2000; 97: 6826–6831. 103. Henriksson BG, Soderstrom S, Gower AJ et al. Hippocampal nerve growth factor levels are related to spatial learning ability in aged rats. Behav Brain Res 1992; 48:15–20. 104. Holtzman DM, Li Y, Chen K et al. Nerve growth factor reverses neuronal atrophy in a Down syndrome model of age-related neurodegeneration. Neurology 1993; 43:2668–2673. 105. Broe GA, Grayson DA, Creasey HM et al.

Biochim Biophys Acta 2000; 1477:299–306. 9. Troy CM. Diversity of Caspase Involvement in Neuronal Cell Death. In: Mattson MP, Estus S, eds. Programmed Cell Death: Cellular and Molecular Mechanisms. Elsevier Science, 2000:67–92. 10. Talanian RV, Quinlan C, Trautz S et al. Substrate specificities of caspase family proteases. J Biol Chem 1997; 272:9677–9682. 11. Thornberry NA, Rano TA, Peterson EP et al. A combinatorial approach defines specificities of members of the caspase family and granzyme B.

18. Deveraux QL, Leo E, Stennicke HR et al. Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases. Embo J 1999; 18: 5242–5451. 19. Chan SL, Griffin WS, Mattson MP. Evidence for caspase-mediated cleavage of AMPA receptor subunits in neuronal apoptosis and Alzheimer’s disease. J Neurosci Res 1999; 57:315–323. 20. Tewari M, Quan LT, O’Rourke K et al. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase.

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