Advances in Immunology, Vol. 59 by Frank J. Dixon (Ed.)

By Frank J. Dixon (Ed.)

With contributions from Steven A. Porcelli and different the world over famous leaders within the box, this quantity keeps the culture of crucial stories. Papers at the CD1 kinfolk, confident collection of thymocytes, and molecular and mobile facets of XLA spotlight the newest quantity.

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As a result of the collaborative efforts of the first workshop meeting, four monoclonal antibodies (NA1/34, OKT6, D47, and M241) were assigned to this cluster. Even at that time, some evidence suggested that there might be heterogeneity within CD1, since biochemical studies showed that the heavy-chain component of the antigen recognized by M241 was significantly smaller than that immunoprecipitated by NA1/34 and OKT6. This heterogeneity of human CD1 was confirmed as more monoclonal antibodies became available (see Table 111).

One would therefore anticipate finding CD1 genes in all mammals and in birds, and possibly also in lower vertebrate species including fish, reptiles, and amphibians. However, other comparisons of CD1 and MHC sequences using slightly different methods than those employed here have suggested that CD1 and MHC may have diverged around the time of the bird-mammal divergence approximately 250-300 million years ago (Hughes, 1991). If so, then CD1 genes may not be present in birds or more ancient vertebrate lineages.

It is noteworthy that these complexes are immunoprecipitated by anti-CD8 mAbs, but only weakly or not at all by anti-CDla mAbs, suggesting that the C D l a determinants are buried in the complex or that the conformation of the protein is altered. The basis for the interaction of the CD8a and C D l a polypeptides is not known, but it has been speculated that the Cys-Lys-Cys sequence in the cytoplasmic tail of CD8a may lie in close proximity to the Cys-Phe-Cys contained in the cytoplasmic tail of CDla, with obvious potential for interchain disulfide bond formation.

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